Robert Neville is alone, the soul surviving human in Los Angeles, a city that once housed millions. The rest of the population has been changed. Transformed by a virus of unknown origin, what were once rational people now stalk the city at night in search of blood. The story is the same the world over. For some reason Robert is immune to the sickness.
At night he barricades himself in his home. Vampires regularly congregate outside trying to find a way in. Crucifixes and mirrors of old vampire folklore ward off some, but not all.
By day he hunts. Searching the dark places of the ruined city for the creatures and killing them with a stake through the heart.
But vampires are not the only demons he must fight. He must also live with the demons in his own mind as the crushing loneliness threatens his very sanity. His only hope is to find a cure for the sickness and bring humanity back from the brink.